Luc Friboulet

Luc Friboulet (PhD) is an INSERM Research Director and team leader at INSERM U981 at Gustave Roussy (Université Paris-Saclay). He is an ERC Principal Investigator and leads a translational research program dedicated to tumor adaptation to targeted therapies.
His work addresses cancer cell plasticity and early drug-tolerant persister states emerging under kinase inhibition. By integrating analyses of repeated patient biopsies with patient-derived experimental models, his team identifies adaptive trajectories under treatment and proposes rational therapeutic strategies to delay or prevent therapeutic failure.
He is the scientific coordinator of the institutional program UNLOCK, focused on anticipating and targeting early adaptive resistance mechanisms in precision oncology.