1) High light Mary Poupot’s project: anti-TAM project

• development of a lung cancer xenografted mouse model for human tumor associated macrophages targeting thanks to the fluorescent 6-25 mAb recognizing only M2 macrophages.

• depletion of human M2 tumor associated macrophages in the lung cancer xenografted mouse model with intravenously treatment with the 6-25-PBD (antibody drug conjugate) and stop of the tumor growth.

2) Development of panels for the identification of sarcomatoid lung tumors and the CD27-CD70 axis (HEGP/Cochin  Team C Gonnin/ E Tartour/ D Damotte, Audrey Lupo-Manset, M Wislez)
We have developed various panels to better characterize the interactions between CD27 and CD70 in sarcomatoid lung tumors, particularly between stromal cells (fibroblasts) and immune cells (T-CD4 lymphocytes, CD8 lymphocytes, macrophages, B lymphocytes). Another panel to clearly differentiate the epithelial and mesenchymal components of sarcomatoid tumors is also currently being validated.

3) A letter of intent, coordinated by Sandra Ortiz (Centre Léon Bérard) and Marie Wislez (Hôpital Cochin, APHP), titled 'Mechanisms of resistance to immunotherapy and targeting the CD70/CD27 axis in pulmonary sarcomatoid carcinomas', has been submitted and accepted by INCA.
Various teams from the CoALA network are involved in this project (See below)